Abstract
715
Jiang, W.G.; Puntis, M.C.A.; Horrobin, D.F.; Scott, C.; Hallett, M.B.
Inhibition of neutrophil respiratory burst and cytokine priming by gamma-linolenic acid
Br J Surgery 1996; 83(5): 659-664.


Abstract

The effect of n-6 fatty acids, particularly gamma-linolenic acid (GLA), on the oxidase response and neutrophil priming by tumour necrosis factor alpha and interleukin 8 was studied in both normal volunteers and patients with obstructive jaundice. GLA inhibited the neutrophil respiratory burst at concentrations higher than 50 mummol/l, but abolished cytokine priming at concentrations as low as 1 mummol/l. Inhibition was not the result of either cytotoxicity to the neutrophils or alteration in cytosolic free calcium homoeostasis. It is concluded that GLA is a potential inhibitor of neutrophil priming by cytokines and of the oxidative response.


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