Abstract
740
Horrobin, D.F. and Ziboh, V.A.
The importance of linoleic acid metabolites in cancer metastasis and in the synthesis and actions of 13-HODE [review]
Adv Exp Med Biol 1997; 433: 291-4.


Abstract

Large scale human epidemiological studies indicate that high intakes of linoleic acid protect against the development of cancer. One mechanism may be the generation of 13-HODE from linoleic acid. 13-HODE prevents cell adhesion to endothelial cells and can inhibit cancer metastasis. 13-HODE synthesis is enhanced by cyclic AMP. Gamma-linolenic acid, a desaturated metabolite of linoleic acid, causes substantial stimulation of 13-HODE synthesis. A fall in gamma-linolenic acid synthesis with age may be related to the age-related fall in 13-HODE


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