Karmali, R.A.; Horrobin, D.F.; Ally, A.I.; Manku, M.S.; Karmazyn, M.; Morgan, R.O.; Menezes, J.
Adenosine as a prostaglandin antagonist. Possible mechanism of the defect in combined immunodeficiency disease due to adenosine deaminase deficiency
Res Commun Chem Pathol Pharmacol 1978; 19(1): 181-4.


Adenosine inhibition of cell division in EB-virus-transformed human lymphocytes and in normal lymphocytes stimulated by phytohemagglutinin can be overcome by prostaglandin (PG) E2. Analysis of adenosine/PGE2 interactions in smooth muscle suggests that adenosine causes immuno-deficiency by blocking a PG-dependent calcium stage of lymphocyte activation.

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