Strong, A.M.; Horrobin, D.F.; Manku, M.S.; Huang, Y.S.
Prostaglandin precursors in plasma phospholipids of patients with psoriasis: effects of treatment with coal tar
Prostaglandins Leukot Med 1984; 14(2): 185-90.


Plasma phospholipids of patients with psoriasis have significantly reduced levels of dihomogammalinolenic acid (20:3n-6), arachidonic acid (20:4n-6) and adrenic acid (22:4n-6), the precursors of the 1, 2 and homo-2 series of prostaglandins (PGs). Concentrations of the 3 series PG precursor, eicosapentaenoic acid (20:5n-3) were normal. Hospital treatment with a coal tar regime produced a rise in 20:3n-6 to levels which were significantly above normal.

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