Hudson, C.J.; Kennedy, J.L.; Gotowiec, A.; Lin, A.; King, N.; Gojtan, K.; Macciardi, F.; Skorecki, K.; Meltzerl, H.Y.; Warsh, J.J.; Horrobin, D.F.
Genetic variant near cytosolic phospholipase A2 associated with schizophrenia
Schizophr Res 1996; 21(2): 111-116.


Two studies were undertaken to determine a possible genetic basis for alterations in phospholipid metabolism in schizophrenia. Initial results demonstrated an association in 65 schizophrenics compared with a matched normal control population. A follow-up haplotype relative risk study of 44 triads (mother, father, affected offspring), confirmed the results seen in the association study. Results suggest that a genetic variant near the promotor region of the gene for cytosolic phospholipase A2, the rate-limiting enzyme in the synthesis of prostaglandins from arachindonic acid, is associated with schizophrenia.

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