Hrelia, S.; Pession, A.; Buda, R.; Lorenzini, A.; Horrobin, D.F.; Biagi, P.L.; Bordoni, A.
Concentration- and time-dependent effects of gamma-linolenic acid supplementation to tumor cells in culture
Prostaglandins Leukot Essent Fatty Acids 1999; 60(4): 235-41.


Gamma-linolenic acid (GLA) supplemented to neuroblastoma SK-N-BE, tubal carcinoma TG and colon carcinoma SW-620 cells was incorporated into phospholipids in all the cell lines (although to different extents), in a concentration- and time-dependent manner. All the cell lines were able to metabolize GLA to arachidonic acid, SK-N-BE being the most active. Supplementation with low GLA concentrations for short periods was not sufficient to impair cell proliferation; only higher amounts of GLA had an anti-proliferative effect also in short times. In these conditions, the antiproliferative effect of GLA is probably due to cellular dysfunction caused by fatty acid modifications.

All copyrights acknowledged

© Peter Lapinskas 1999-2012 Email Peter Lapinskas Last updated: 3 July 2012

Home      Services      Background      Publications      Resources      Contact