Bennett, C.N. and Horrobin, D.F.
Gene targets related to phospholipid and fatty acid metabolism in schizophrenia and other psychiatric disorders: an update [review]
Prostaglandins Leukot Essent Fatty Acids 2000; 63(1): 47-59.


Phospholipids make up about 60% of the brain's dry weight and play key roles in many brain signal tranduction mechanisms. A recent review(1)identified the increasing evidence that abnormal phospholipid and related fatty acid metabolism may contribute to illnesses such as schizophrenia, bipolar disorder, depression and attention deficit hyperactivity disorder. This current paper reviews the main pathways of phospholipid metabolism, emphasizing the role of phospholipases of the A2 in signal tranduction processes. It also updates the chromosomal locations of regions likely to be involved in these disorders, and relates these to the known locations of genes directly or indirectly involved in phospholipid and fatty acid metabolism.

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© Peter Lapinskas 1999-2012 Email Peter Lapinskas Last updated: 3 July 2012

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